ABO BLOOD GROUPS IN CORRELATION WITH HYPERLIPIDEMIA, DIABETES MELLITUS TYPE II AND ESSENTIAL HYPERTENSION

Objectives: There are associations between ABO blood groups and systemic diseases. So we aim to explore any associations among ABO blood groupwith hyperlipidemia; diabetes mellitus (DM) type II, and essential hypertension.Methods: A total of 800 subjects were recruited. Patients groups were subdivided into hyperlipidemia group (n=100), DM type II group (n=160),and hypertension group (n=166). Fasting blood sample was collected and plasma samples used for measuring of 2, 3-dinor-6-keto-prostaglandinF1α (PGF1α), 11-dehydro-thromboxane (TX) B2, insulin, triglycerides (TGs), total cholesterol (Tc), high-density lipoprotein cholesterol (HDL-C),prothrombin time (PT), activated partial PT (aPPT), blood group type, random blood glucose level, and body mass index (BMI) were also determined.Results: Blood Group A demonstrates a significant elevation in insulin, random blood sugar (RBS), Tc, TGs, and low-density lipoprotein (LDL)/HDLratio and shows a significant decrease in prostacyclin. Blood group B demonstrates a significant elevation in TXB, Tc, TGs, and LDL/HDL ratio andshows a significant decrease in PT. Blood group AB demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease ininsulin, RBS, Tc, TGs, and LDL/HDL. Blood group O demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease inTXB2, Tc, TGs, and LDL/HDL ratio.2Conclusions: Blood group AB is protective against hyperlipidemia, diabetes, thrombosis, and hypertension, blood group O is protective againstcardiovascular diseases while blood group B followed by A are risk factors for hypertension and blood group A is a risk factor for diabetes. Thesefindings are establishing the ethnic-dependent correlation of ABO groups and studied diseases.Keywords: Hyperlipidemia, DM type II, Hypertension, Thrombosis, ABO blood groups

Comparison of three data-driven techniques in modelling the evapotranspiration process.

Evapotranspiration is one of the main components of the hydrological cycle as it accounts for more than two-thirds of the precipitation losses at the global scale. Reliable estimates of actual evapotranspiration are crucial for effective watershed modelling and water resource management, yet direct measurements of the evapotranspiration losses are difficult and expensive. This research explores the utility and effectiveness of data-driven techniques in modelling actual evapotranspiration measured by an eddy covariance system. The authors compare the Evolutionary Polynomial Regression (EPR) performance to Artificial Neural Networks (ANNs) and Genetic Programming (GP). Furthermore, this research investigates the effect of previous states (time lags) of the meteorological input variables on characterizing actual evapotranspiration. The models developed using the EPR, based on the two case studies at the Mildred Lake mine, AB, Canada provided comparable performance to the models of GP and ANNs. Moreover, the EPR provided simpler models than those developed by the other data-driven techniques, particularly in one of the case studies. The inclusion of the previous states of the input variables slightly enhanced the performance of the developed model, which in turn indicates the dynamic nature of the evapotranspiration process

Harmonic signals in Saudi Arabia industrial plants

Results of a preliminary survey of harmonic levels within the Saudi Arabian power network and industrial facilities are presented. The major industries are petrochemical related and a number of arc furnaces. The voltage and current harmonic levels are within the IEEE 519-1992 standard. The results indicate a growing level of harmonics as more and more petrochemical industries are connected to the network

Harmonic signals in Saudi Arabia industrial plants

Results of a preliminary survey of harmonic levels within the Saudi Arabian power network and industrial facilities are presented. The major industries are petrochemical related and a number of arc furnaces. The voltage and current harmonic levels are within the IEEE 519-1992 standard. The results indicate a growing level of harmonics as more and more petrochemical industries are connected to the network

Studies on Some Parasitic Diseases in Oreochromis niloticus Fish Hatchery with Emphasis to Life Stages

This study was conducted on 210 Oreochromis niloticus (O. niloticus) of different life stages including (100 fry, 100 fingerlings and 10 broodstocks) obtained from a private fish hatchery at Kafer El-Sheikh Governorate, Egypt; during August 2014. The hatchery complains 30% mortality among fry and fingerlings while no mortalities was recorded among broodstocks. Parasitological examination revealed heavy infestation with Triochodina species (sp.) in all examined life stages at a prevalence rate 100%. In addition, Gyrodactylus sp. was recorded in gills of fry, fingerlings and broodstocks at a rate of 5, 12, and 10 %, respectively. Kidneys and gills of all examined life stages showed heavy infestations with Myxosporean sp., with 100 % prevalence rate. Haemogregarina sp. was described in the blood of fingerlings and gill tissues of broodstocks. Additionally, Encysted metacerceria was observed in gills of broodstocks. The recovered parasites were demonstrated hisopathologically in the gill and kidney tissues of the examined fish. The histopathological examination revealed that the infested gills exhibited serious lesions such as hyperplasia and hypertrophy of the lining epithelial cells of the gill filaments, fusion and necrosis of secondary lamellae and vasodilatation. The lining epithelium of the renal tubules showed degenerative and necrotic changes with the presence of various developmental stages of myxosporidia. In conclusion, fry and fingerlings exhibited high mortalities, while no mortality was recorded among broodstocks, regardless the intensity of infestation and severity of pathological alterations which was intense in broodstocks

An on-line neural network-based harmonic analyzer

This paper introduces a simple solution, based on neural networks, to the problem of the on-line and adaptive harmonic component analysis in power systems. A single neuron is used whose synaptic weights are directly related to the signal's dc component and to the magnitudes and phases of the harmonic components present in the signal. In addition, deviation from the nominal fundamental frequency is accounted for in the same context. The simulation of a realistic test case shows a very efficient and precise estimation of the present harmonic

An on-line neural network-based harmonic analyzer

This paper introduces a simple solution, based on neural networks, to the problem of the on-line and adaptive harmonic component analysis in power systems. A single neuron is used whose synaptic weights are directly related to the signal's dc component and to the magnitudes and phases of the harmonic components present in the signal. In addition, deviation from the nominal fundamental frequency is accounted for in the same context. The simulation of a realistic test case shows a very efficient and precise estimation of the present harmonic

DESIGN, SYNTHESIS AND COX1/2 INHIBITORY ACTIVITY OF NEW QUINAZOLINE-5-ONE DERIVATIVES

A new series of 1-(4-Acetylphenyl)-7,7-dimethyl-3-(substitutedphenyl)-1,2,3,4,7,8-octahydroquinazolin-5(6H)-ones (6-15) were synthesized and tested against COX-1 and COX-2 enzymes. Those compounds exhibited strong interaction at the COX-2 binding site and poor interaction at the COX-1 active site. Subjected to in vitro cyclooxygenase COX-1/COX-2 inhibition assay; most of the compounds especially compounds 6, 7, 12, 13, and 16 exhibited potent anti-inflammatory effects, selective COX-2 inhibition, with half-maximal inhibitor concentration (IC50) values of 0.22–1.42 μM and selectivity index (SI) values of 6.16–14.18 compared with celecoxib (IC50 = 0.05 μM and COX-2 SI: 296), diclofenac (IC50 = 0.8 μM and COX-2 SI: 4.87), and indomethacin (IC50 = 0.49 μM and COX-2 SI: 0.08) as reference drugs. Docking study has been carried out to confirm the binding affinity and selectivity of the most active compound (compound 6) to COX-2 enzyme

Effect of Treated Oily Waste Water of Khartoum Refinery on Nubian Goat Kids

One of the very many imposed environmental threats of the petroleum industry internationally is its effluent of treated oily waste water (TOWW), which was reported causing mortalities in small ruminants. This study was carried out to investigate the toxic effects of TOWW of Khartoum Refinery Company (KRC) on Nubian goat kids. Twentyone goat kids were divided into three groups: Group A (control), arranged in 1x3, and B and C (test groups) arranged in 2x3x3. Each test group was divided into three subgroups; B1, B2 and B3 and C1, C2 and C3. Groups B and C were watered for 6 weeks from KRC oxidation ponds II and III, respectively, diluted at ratios of 1:0, 1:1 and 1:2 with tap water respective to subgroups 1, 2 and 3. The control group was tap watered. All groups were fed on a basal ration of 2.86 Mcal ME/kg and crude protein 20.88% energy concentration meeting goat daily requirements. Clinical signs and mortalities were daily observed. Body weights were recorded fortnightly. Blood and serum samples were collected fortnightly for haematological (RBCs, Hb, PCV, WBCs and their differentials) and serum metabolites (glucose, total protein, albumin and globulin), enzymes (AST and ALP) and electrolytes (Ca, P, Co, Cu, Fe and Mn) examinations. Organs samples for histopathological investigations were collected on post mortem examinations or in extremis slaughter. All test groups significantly (P≤ 0.05) lost weight with variations in the total water consumption and similar average water consumption for all subgroups except C3 (P≤0.05). All test groups showed decreased appetite, diarrhoea, weakness and partial paralysis. The mortality was 100%, 66.6% and 33.3% in subgroups C1, C2 and C3, respectively. The mortality was 66.6% in subgroup B3 and 33.3% in each of B2 or B1. Haematologically, test goats were neither anaemic nor infected with haemodilutions (P≤0.05) in subgroups B3, C2 and C3. All test groups showed congestion or haemorrhage in the intestinal submucosa, with detachment of epithelium or detachment of the villi, in response to the osmotic diarrhoea. All test groups showed no significant (P>0.05) changes in serum metabolites, electrolytes or serum enzymes, but livers were congested, stressed and engorged. Bile and kidney showed shrinkage, necrosis of the glomeruli, congestion and haemorrhage in the cortical and medullary tubules. These signs were indications of intensive mineral excretion. It is concluded that TOWW from KRC has toxic effects on Nubian goat kids judged by the early mortalities and by the clinical signs of diarrhoea and recumbency, metabolic disturbances in the liver with histopathological changes in various body systems. It is recommended that TOWW initial concentration be restored by addition of equivalent water to reduce or abolish its toxic manifestations